I have several custom HUD profiles configured in my list. :)
I change them fairly often while testing things.
If the changes aren't applying for you please attach your PokerTracker4.log file from C:\Users\yourname\AppData\Local\PokerTracker 4\ (which you can access from the PT4 File menu) to a
Support Ticket and attach
screenshots to illustrate what you're doing and what you see.